Ivermectin Albendazole

Description

Ivermectin & Albendazole Tablets – Broad-Spectrum Deworming and Antiparasitic Treatment
What is Ivermectin Albendazole?
Ivermectin + Albendazole is a potent antiparasitic combination therapy used to treat a wide range of intestinal and tissue-dwelling parasitic infections.
Ivermectin: A broad-spectrum antiparasitic that works by paralyzing and killing parasites.
Albendazole: A benzimidazole anthelmintic that inhibits the metabolism of parasitic worms.
Composition
Ivermectin: 6 mg / 12 mg (varies by formulation)
Albendazole: 400 mg
Form: Oral tablet
Mechanism of Action
Ivermectin:
Binds to glutamate-gated chloride ion channels in the nerve and muscle cells of parasites, leading to increased cell membrane permeability, paralysis, and death of the parasite.
Albendazole:
Inhibits microtubule formation in parasite cells by binding to β-tubulin, impairing glucose uptake and leading to energy depletion and death of the parasite.
Indications / Uses
✅ Common Indications:
Strongyloidiasis
Ascariasis (roundworm)
Trichuriasis (whipworm)
Hookworm infections
Lymphatic Filariasis (Wuchereria bancrofti)
Cutaneous Larva Migrans
Neurocysticercosis (involving Albendazole only – Ivermectin may not be used)
Onchocerciasis (river blindness) – Ivermectin only
🌍 Mass Drug Administration (MDA):
In many countries, this combination is used in public health campaigns for deworming programs to eliminate soil-transmitted helminths and filarial infections.
Dosage and Administration
💊 Dosage should be prescribed by a physician based on patient weight, age, and type of infection.
Typical Adult Dosage:
Ivermectin: 6–12 mg as a single dose
Albendazole: 400 mg as a single dose or once daily for 3–5 days
Dosing Frequency:
For deworming: Often given annually or biannually
For treatment: May require 1–5 days of therapy depending on the condition
Administration:
Take with food to enhance Albendazole absorption.
Preferably in the morning.
Benefits
Convenient single-tablet formulation for better patient compliance
Useful in mass deworming and public health programs
Oral administration – no injection required
Safe and effective in adults and children (age and weight-dependent)
Side Effects
Common Side Effects:
Nausea
Abdominal pain
Headache
Dizziness
Diarrhea
Skin rash or itching
Less Common / Serious Reactions:
Fever or chills
Elevated liver enzymes
Vision disturbances (rare)
Neurological effects in neurocysticercosis (use with corticosteroids)
Allergic reactions
⚠️ Medical monitoring is advised in patients with high parasite loads or CNS involvement.